Tuesday, October 14, 2008


There are several types of thyroid cancer: papillary, follicular, medullary, anaplastic, and variants.

Papillary and follicular thyroid carcinomas ~~Referred to as well-differentiated thyroid cancer and account for 80–90% of all thyroid cancers. Variants include tall cell, insular, columnar, and Hurthle cell. Their treatment and management are similar. If detected early, most papillary and follicularthyroid cancer can be treated successfully.

Medullary thyroid carcinoma (MTC) ~~ Accounts for 5-10% of all thyroid cancers. Medullary cancer is easier to treat and control if found before it spreads to other parts of the body. There are two types of medullary thyroid cancer: sporadic and familial. Genetic testing (of the RET protooncogene should be performed in all patients with MTC to determine whether there are genetic changes that predict the development of MTC. In individuals with these genetic changes, removal of the thyroid during childhood has a high probability of being curative.

Anaplastic thyroid carcinoma ~~ The least common and accounts for only 1–2% of all thyroid cancer. This type is difficult to control and treat because it is a very aggressive type of thyroid cancer.

Treatments for thyroid cancer include surgery, radioactive iodine treatment, external beam radiation therapy, and chemotherapy. In most cases, patients undergo surgery to remove most of the thyroid gland, and are treated with thyroid hormone replacement therapy.

For those with papillary and follicular thyroid cancer, the dose of thyroid hormone replacement is usually high enough to suppress thyroid stimulating hormone (TSH) well below the range that is normal for someone not diagnosed with thyroid cancer, to help prevent the growth of cancer cells while providing essential thyroid hormone to the body.

Factors associated with thyroid cancer include a family history of thyroid cancer, gender (women have a higher incidence of thyroid cancer), age (the majority of cases occur in people over 40, although thyroid cancer affects all age groups from children through seniors), and prior exposure of the thyroid gland to radiation.

While the prognosis for most thyroid cancer patients is very good, the rate of recurrence can be up to 30%, and recurrences can occur even decades after the initial diagnosis. Therefore, it is important that patients get regular follow-up examinations to detect whether the cancer has re-emerged. Monitoring should continue throughout the patient’s lifetime.

Periodic follow-up examinations can include a review of the medical history together with selected blood tests appropriate for the type of cancer and stage of treatment (TSH, thyroglobulin, CEA, and calcitonin levels), physical examination, and imaging techniques (ultrasound, radioiodine whole body scan, chest X-ray, CT, MRI, PET, and other tests).

Metatastic Thyroid Cancer (spread to distant locations)
Guidelines from American Thyroid Association (2006)

The guidelines cover diagnosis, surgery, staging, radioiodine ablation, post-therapy scans, TSH suppression, thyroglobulin testing, ultrasound, RAI scans, other imaging techniques, metastatic disease, and many other topics. The thyroid cancer specialist physicians who developed the guidelines included many Thyroid Cancer medical advisors and conference and workshop speakers.

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